A recent article by the team of Sergio Lira describes a new experimental model of Ulcerative Colitis that accurately reflects the cycling inflammation of the disease. The authors show that changes in the diet resulted in changes in the gut microflora which ultimately induced the disease.
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Preliminary work in mouse models showed that the composition of the gut microbiome could predict the response of animals to a new type of anti-cancer drug, immune checkpoint inhibitors. Recently, this work was validated in patients with cancer.
Carrie Falling is a PhD student at the University of Otago and is carrying out a study on pain in people with IBD.
A recent study from Canada showed that "people living in rural households had lower risk of developing IBD. This association is strongest in young children and adolescents, and in children exposed to the rural environment early in life."
Rotavirus infection of the intestine is a major cause of diarrhoea in infants and children. New research has identified an immune pathway within gut epithelial cells that can detect the virus early and restrict its growth.
Looking beyond what is visible to the naked eye makes the world a much more interesting place.
Scientists in Ireland have linked the gut microbiome with anxiety disorders. The researchers showed that germ-free mice, mice with no gut bacteria, had changes in the part of the brain that controls emotions.
Scientists in the US have recently shown the feasibility of growing intestines in the lab, complete with nerves and muscles.