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Restoring intestinal epithelial cell energy:
Creatine supplementation may help restore intestinal barrier function in inflammatory bowel disease:
Inflammatory bowel diseases (IBD) are characterised as the chronic inflammation of the digestive tract leading to the disruption of the intestinal epithelial cell lining. The intestinal epithelial cells have been shown to ineffectively use the energy from key molecules such as butyrate (a bacterial metabolite energy source) and creatine (an energy storer molecule) which restricts epithelial regeneration and barrier formation in IBD. In this study, the researchers used intestinal epithelial cell models (colonoids) derived from mice colonic biopsies to understand how the loss in the creatine kinase energy systems affects energy production and epithelial function.
The results from this study showed that a loss in creatine kinase led to an altered creatine energy pathway, energetic stress, and reduced intestinal epithelial cell function. An oral supplementation of phosphocreatine given to mice showed that this could potentially rescue the intestinal epithelial cell defects and restore the creatine kinase energy pathways.
This research indicates that creatine kinase supplementation may be a potential new strategy to help restore the creatine kinase energy levels to support intestinal epithelial cell barrier function in IBD.
Source: https://www.cmghjournal.org/article/S2352-345X(25)00098-0/fulltext